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What is a ACTIVATED PROTEIN C RESISTANCE: APCR?

Activated Protein C Resistance (APCR) is a blood test that evaluates how effectively activated protein C can regulate blood clotting. Reduced sensitivity to activated protein C may indicate an increased tendency to form abnormal blood clots, often associated with Factor V Leiden. The test is needed to investigate unexplained or recurrent venous thrombosis, assess inherited clotting disorders, and help evaluate individuals with a suspected predisposition to abnormal blood clot formation.

Additional Information

Also known as/ Other names: Activated Protein C Resistance (APCR), APC Resistance Test, Factor V Leiden Test, Coagulation Assay for APC Resistance
Parameters: 1
Recommended for: M/F/Others
Sample Type: Blood
Patient Preparation: Overnight fasting is preferred
Reports: 3 days

FAQs

What is activated protein C resistance?

It is a condition in which the blood-clotting system responds inadequately to activated protein C, potentially allowing clotting activity to continue for longer than normal.

What is Factor V Leiden?

Factor V Leiden is an inherited genetic change in the factor V clotting protein that can make it resistant to activated protein C and increase the risk of venous thrombosis.

Does a positive APCR result mean I have Factor V Leiden?

Not necessarily. APCR can suggest resistance to activated protein C, but genetic testing for the Factor V Leiden mutation may be needed to confirm the specific cause.

Why might my doctor order an APCR test after a blood clot?

It may be considered when a blood clot occurs at a young age, is recurrent, occurs without an obvious trigger, or there is a personal or family history suggesting inherited thrombophilia.

What does an abnormal APCR result mean?

An abnormal result indicates reduced sensitivity to activated protein C. Further testing may be required to determine whether Factor V Leiden or another factor is responsible.

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