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What is a BCR-ABL GENE REARRANGEMENT QUANTITATIVE BY RT-PCR?

The BCR-ABL Gene Rearrangement Quantitative by RT-PCR test is a molecular diagnostic test used to detect and measure the BCR-ABL fusion gene, which results from a chromosomal translocation known as the Philadelphia chromosome. This abnormal gene is commonly associated with chronic myeloid leukemia (CML) and some cases of acute lymphoblastic leukemia (ALL). The test is performed to confirm diagnosis, monitor disease progression, and assess treatment response, especially in patients receiving targeted therapies like tyrosine kinase inhibitors.

Additional Information

Also known as/ Other names: BCR-ABL Quantitative PCR, BCR-ABL Transcript Quantification, Philadelphia Chromosome Quantitative RT-PCR
Parameters: 1
Recommended for: M/F/Others
Sample Type: Blood
Patient Preparation: Minimum gap from Chemotherapy should be 2 weeks
Reports: Next Day

FAQs

Why is this test important?

It confirms diagnosis, monitors disease progression, and evaluates treatment response, especially for patients receiving tyrosine kinase inhibitors.

What happens if the test is positive?

A positive result confirms the presence of the BCR-ABL fusion gene, supporting diagnosis and treatment planning.

What does a negative result mean?

It suggests no detectable BCR-ABL fusion gene, ruling out CML or BCR-ABL–positive ALL.

Can medications affect the test results?

No, medications do not interfere with genetic transcript detection.

Is this test safe for children?

Yes, it is safe and can be performed in pediatric patients when clinically indicated.

What are the risks of not testing?

Without testing, diagnosis may be delayed, and treatment effectiveness cannot be properly monitored.

Can BCR-ABL mutations be prevented?

No, they are genetic changes, but early detection helps guide therapy.

What conditions are linked to positive results?

Positive results are associated with chronic myeloid leukemia and some acute lymphoblastic leukemia cases.

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