CD33 Flow Cytometry is a laboratory test that detects and measures CD33, a protein primarily expressed on myeloid cells and certain immature blood-forming cells. Using flow cytometry, it helps identify and characterize myeloid cell populations in blood, bone marrow, or tissue samples. The test is needed to support the diagnosis and classification of acute myeloid leukemia and other myeloid disorders by evaluating abnormal cellular marker patterns.
CD33 may be useful when evaluating suspected acute myeloid leukemia, myelodysplastic syndromes, myeloid neoplasms, and other conditions involving abnormal myeloid cells.
No. CD33 is one marker within a broader immunophenotyping panel. Diagnosis requires correlation with other markers, blood counts, cell morphology, clinical findings, and sometimes genetic or molecular testing.
CD33-positive means that the evaluated cells express CD33. This can support myeloid differentiation, but the significance depends on the cell population, expression intensity, and other marker results.
CD33-negative means that significant CD33 expression was not detected in the evaluated population. This finding should be interpreted alongside the complete immunophenotyping profile.
Yes. CD33 is normally expressed on various myeloid cells, including monocytes and certain immature myeloid precursor cells. Its expression may vary according to cell maturity.
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