CD34 Flow Cytometry is a laboratory test that detects and measures CD34, a marker commonly expressed on hematopoietic stem and progenitor cells. Using flow cytometry, it helps identify and quantify immature blood-forming cells in blood or bone marrow samples. The test is needed to support the diagnosis and classification of leukemias and other hematological disorders, assess abnormal blast populations, and evaluate stem-cell populations for clinical purposes.
It may assist in evaluating acute leukemias, myelodysplastic and other myeloid disorders, and conditions involving abnormal or increased populations of immature blood-forming cells.
No. CD34 is one marker used in a broader immunophenotyping panel. Diagnosis requires correlation with other markers, blood counts, cell morphology, clinical findings, and sometimes genetic or molecular testing.
CD34-positive means that the evaluated cells express CD34. It generally indicates an immature hematopoietic or progenitor cell population, although CD34 expression is not completely specific.
CD34-negative means that significant CD34 expression was not detected on the evaluated cells. Some normal and abnormal blood cells naturally do not express CD34.
Yes. Small numbers of CD34-positive hematopoietic progenitor cells normally circulate in peripheral blood. Their numbers can increase during certain treatments or mobilization procedures.
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