Abnormal CBC or ESR results can point to a variety of health issues. If your red blood cell count or hemoglobin is low, it could be a sign of anemia. If your white blood cell count is unusually high or low, that might indicate an infection, an immune system problem, or, in some cases, a blood disease. As for the ESR, a high sedimentation rate usually signals inflammation and can be seen with conditions like arthritis, autoimmune diseases, or infections.