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What is a Comprehensive Genomic Profile -500 Gene Pane?

Comprehensive Genomic Profile - 500 Gene Panel is an advanced next-generation sequencing (NGS) test that analyzes 500+ cancer-related genes from tumor tissue (usually FFPE). It detects a wide range of genomic alterations including mutations, insertions/deletions, copy number variations, gene fusions, and biomarkers like TMB (Tumor Mutational Burden) and MSI (Microsatellite Instability). This panel helps oncologists identify actionable mutations, guide targeted therapy selection, determine eligibility for clinical trials, and provide personalized treatment strategies for patients with solid tumors or advanced cancers.

Additional Information

Also known as/ Other names: Comprehensive Cancer Genomic Panel, 500 Gene NGS Panel, Comprehensive Molecular Profiling, Expanded Oncology Gene Panel
Parameters: 1
Recommended for: M/F/Others
Sample Type: FFPE Tissue block
Patient Preparation: Sample should pass the DNA QC process. In case QC fails patients will be informed within 8-10 days.
Reports: 5-6 weeks

FAQs

Can this test replace standard biomarker testing?

It is a comprehensive test that often includes and expands beyond standard single-gene tests like EGFR, BRAF, or KRAS.

Who should undergo this 500 Gene Panel?

It is recommended for patients with advanced, metastatic, or rare solid tumors where standard treatment is not effective.

What is the difference between 500 Gene Panel and smaller panels?

The 500 Gene Panel is much broader, covering more genes, rare alterations, TMB, and MSI compared to limited 10-50 gene panels.

How accurate is the Comprehensive Genomic Profile - 500 Gene Panel?

It uses high-sensitivity NGS technology with excellent accuracy. Positive findings are usually confirmed with orthogonal methods for clinical reliability.

What if no actionable mutation is found?

No actionable mutation means standard therapies or clinical trials based on other factors may be considered. It still provides valuable information.

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