Cortisol Serum (Morning Sample) is a blood test that measures the level of cortisol, a hormone produced by the adrenal glands, usually collected in the morning when cortisol levels are naturally higher. The test is needed to evaluate adrenal gland function and investigate conditions associated with abnormal cortisol production, such as adrenal insufficiency or Cushing syndrome. It may also help assess certain hormonal or endocrine disorders.
No. Cortisol testing measures cortisol itself, while an ACTH test measures adrenocorticotropic hormone, which helps regulate cortisol production by the adrenal glands.
Cortisol normally follows a circadian rhythm, with higher levels in the morning and lower levels later in the day. The timing of testing is therefore important for interpretation.
Usually not. Evaluation for Cushing syndrome may require additional tests, such as late-night salivary cortisol, urine free cortisol, or a dexamethasone suppression test.
Not always. Depending on the result and clinical circumstances, an ACTH stimulation test or other investigations may be required to confirm adrenal insufficiency.
Yes. Physical or emotional stress can temporarily increase cortisol levels. Acute illness, strenuous exercise, and inadequate sleep may also influence results.