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What is a CYSTIC FIBROSIS IMMUNE REACTIVE TRYPSINOGEN , IRT (NEONATAL SCREEN)?

Cystic Fibrosis Immunoreactive Trypsinogen (IRT) is a blood test used as part of newborn screening for cystic fibrosis, an inherited disorder affecting the lungs, digestive system, and other organs. IRT levels are typically elevated in babies with cystic fibrosis. The test is needed to identify newborns who may require further evaluation, enabling early diagnosis and appropriate care to help manage potential complications.

Additional Information

Also known as/ Other names: IRT Neonatal Screening Test, Immunoreactive Trypsinogen (IRT) Test, Newborn Screening for Cystic Fibrosis, Cystic Fibrosis IRT Screen
Parameters: 1
Recommended for: M/F/Others
Sample Type: Blood
Patient Preparation: Drug history is required.
Reports: 3 days

FAQs

What is cystic fibrosis?

Cystic fibrosis is a genetic disorder caused by changes in the CFTR gene, resulting in abnormal salt and water movement across cells and thick, sticky secretions.

What does a high IRT level mean?

A high IRT level may indicate an increased possibility of cystic fibrosis, but it does not confirm that the baby has CF.

Does a normal IRT result rule out cystic fibrosis?

Not completely. Newborn screening reduces the likelihood of CF but cannot detect every affected baby.

What happens if the IRT result is elevated?

The baby may be advised to undergo additional testing, such as CFTR genetic testing and/or a sweat chloride test, depending on the screening protocol.

Is a positive IRT result the same as a diagnosis of cystic fibrosis?

No. IRT is a screening test. Further diagnostic testing is required to confirm or exclude cystic fibrosis.

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