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What is a CYTOKERATIN- 7 (CK-7) BY IHC?

The Cytokeratin-7 (CK-7) by IHC test is an immunohistochemistry procedure used to detect CK-7 protein expression in tissue samples. CK-7 is a cytoskeletal marker commonly expressed in epithelial cells of the lung, breast, ovary, and urinary tract. This test is performed to help pathologists determine the origin of tumors, differentiate between cancer types, and guide treatment decisions. It is particularly useful in distinguishing CK-7 positive carcinomas from CK-7 negative malignancies, ensuring accurate diagnosis and management.

Additional Information

Also known as/ Other names: CK7 Immunohistochemistry, Cytokeratin 7 IHC Stain, CK-7 Marker by IHC, CK7 Immunostaining
Parameters: 1
Recommended for: M/F/Others
Sample Type: FFPE Tissue block
Patient Preparation: No prior preparation is needed
Reports: FFPE Block: 6 days Fresh Tissue: 10 days

FAQs

Can CK-7 by IHC distinguish between primary and metastatic tumors?

Yes, CK-7 expression patterns help differentiate primary tumors from metastases, especially in lung, breast, and ovarian cancers.

Is CK-7 always expressed in breast cancer?

Most breast carcinomas are CK-7 positive, but exceptions exist, so other markers may be used alongside CK-7 for confirmation.

Does CK-7 help in diagnosing lung cancer?

Yes, CK-7 positivity supports diagnosis of adenocarcinoma of the lung, distinguishing it from squamous cell carcinoma which is usually CK-7 negative.

Can CK-7 be used alone for diagnosis?

No, CK-7 is used in combination with other markers like CK-20, ER, PR, and GATA-3 for accurate tumor classification.

What cancers are typically CK-7 negative?

Colorectal carcinoma and hepatocellular carcinoma are usually CK-7 negative, helping distinguish them from CK-7 positive tumors.

Does CK-7 expression vary with tumor grade?

Expression may vary, but CK-7 positivity is generally consistent across tumor grades in CK-7 associated cancers.

Is CK-7 useful in ovarian cancer diagnosis?

Yes, CK-7 positivity supports diagnosis of ovarian carcinoma, especially serous and endometrioid subtypes.

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