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What is a DEXAMETHASONE SUPPRESSION TEST HIGH DOSE FOR CORTISOL?

The High-Dose Dexamethasone Suppression Test is a hormonal test that evaluates how the body’s cortisol production responds to a high dose of dexamethasone, a synthetic steroid. It is primarily used in the evaluation of Cushing syndrome and may help differentiate between certain causes of excessive cortisol production, particularly pituitary-dependent Cushing disease and other sources of ACTH excess.

Additional Information

Also known as/ Other names: High Dose Dexamethasone Suppression Test, HDDST for Cortisol, High Dose DST, Dexamethasone Cortisol Suppression Test (High Dose)
Parameters: 1
Recommended for: M/F/Others
Sample Type: Blood
Patient Preparation: Day 1:Draw fasting Cortisol sample at 8 am. Administer tablet 4 mg Dexamethasone orally at 11 pm at night. Day 2: Draw 2nd specimen at 8 am next morning in fasting condition.
Reports: 2 days

FAQs

Why is the High-Dose Dexamethasone Suppression Test done?

It is mainly used during the evaluation of Cushing syndrome and can help distinguish certain causes of excess cortisol production.

What is cortisol?

Cortisol is a hormone produced by the adrenal glands that helps regulate metabolism, blood pressure, stress responses, and immune function.

What is dexamethasone?

Dexamethasone is a synthetic glucocorticoid that acts similarly to cortisol and can suppress ACTH production under normal physiological conditions.

What is Cushing syndrome?

Cushing syndrome is a condition caused by prolonged exposure to excessive cortisol or cortisol-like hormones.

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