Erythropoietin (EPO) is a blood test that measures the level of erythropoietin, a hormone mainly produced by the kidneys that stimulates the bone marrow to make red blood cells. The test is needed to help evaluate unexplained anemia or an abnormally high red blood cell count and to assess whether EPO production is contributing to these conditions. It can also support the evaluation of certain kidney or bone marrow disorders.
A low EPO level may occur when the kidneys are not producing enough of the hormone or in certain conditions associated with increased red blood cell production.
High EPO levels may occur when the body is responding to low oxygen availability, certain types of anemia, or conditions that cause increased or inappropriate EPO production.
Yes. Healthy kidneys produce most of the body's erythropoietin. Reduced kidney function can decrease EPO production and contribute to anemia.
Measuring EPO can help determine whether the kidneys are producing an appropriate amount of erythropoietin in response to a low red blood cell or hemoglobin level.
Yes. EPO levels can help distinguish between some causes of erythrocytosis or polycythemia, particularly when interpreted alongside other blood tests.