The **Factor II, Functional test**—also known as the Prothrombin Activity Test—measures the activity of Factor II, a key protein involved in blood clotting. It helps evaluate clotting disorders, bleeding tendencies, or monitor anticoagulant therapy. The test is performed by collecting a blood sample, usually after overnight fasting. Patients are advised to discontinue heparin for 1 day and oral anticoagulants for 7 days (with physician approval) before sampling to ensure accurate results.
A low Factor II level may indicate a bleeding disorder, liver disease, or vitamin K deficiency.
Elevated Factor II levels may increase risk of abnormal clotting, such as deep vein thrombosis.
Patients with unexplained bleeding, clotting disorders, or those on anticoagulant therapy may need it.
Vitamin K intake can influence clotting factors, so dietary habits may affect results.
Yes, if monitoring anticoagulant therapy or evaluating persistent clotting abnormalities, repeat testing is necessary.