What is a Ferric Chloride Test for Phenylketonurea Urine Spot?

The Ferric Chloride Test for Phenylketonuria (PKU) Urine Spot is a simple screening test used to detect abnormal metabolites in urine. In PKU, a genetic disorder affecting amino acid metabolism, excess phenylalanine is converted into phenylketones, which react with ferric chloride to produce a characteristic green color. This test helps in the early detection of PKU, allowing timely dietary management to prevent intellectual disability and other complications. It is quick, inexpensive, and useful for initial screening.