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What is a GENEXPERT MTB/XDR?

GeneXpert MTB/XDR is a rapid molecular test that detects Mycobacterium tuberculosis (MTB) DNA in a clinical sample and identifies resistance to key anti-tuberculosis drugs, including isoniazid, fluoroquinolones, and second-line injectable drugs. It is needed to support the rapid diagnosis of tuberculosis and detect drug-resistant TB, helping clinicians select appropriate treatment promptly and reduce the risk of treatment failure and disease transmission.

Additional Information

Also known as/ Other names: Extended Drug Resistant TB PCR Test, TB Drug Resistance Molecular Assay, MTB/XDR Resistance Detection Test
Parameters: 1
Recommended for: M/F/Others
Sample Type: Sputum/FNAC/Biopsy tissue in normal saline/Pus/All body fluids except Urine
Patient Preparation: No prior preparation is needed
Reports: Same Day

FAQs

What does XDR mean?

XDR refers to extensively drug-resistant tuberculosis. The test detects resistance-associated mutations to multiple important anti-TB drugs.

Which drug resistances can the test detect?

Depending on the assay, GeneXpert MTB/XDR detects resistance markers for isoniazid, fluoroquinolones, and certain second-line injectable drugs, along with MTB detection.

Does a positive result confirm active tuberculosis?

Detection of MTB supports tuberculosis infection, but the result should be interpreted along with symptoms, imaging, examination, and other laboratory findings.

Does a negative result completely rule out tuberculosis?

No. A negative result does not always exclude TB, particularly when the bacterial load is low or the sample is inadequate.

Can the test detect drug-resistant TB?

Certainly. It detects specific genetic mutations associated with resistance to several anti-TB drugs.

Does the test determine whether TB is latent or active?

No. GeneXpert MTB/XDR detects MTB genetic material and drug-resistance markers but does not by itself distinguish latent TB infection from active TB disease.

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