It indicates active infection and requires close monitoring as it can cause severe complications including liver failure.

Yes, quantitative HEV-RNA PCR can measure viral load to monitor disease severity and treatment response.

Pregnant women, immunocompromised patients, organ transplant recipients, and people with unexplained acute hepatitis.

PCR detects active virus (current infection), while antibody tests show past or recent exposure.

Yes, it is especially important in immunocompromised patients where Hepatitis E can cause chronic infection.

It is most useful during the acute phase of illness when symptoms like jaundice, fatigue, and liver dysfunction appear.