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What is a HER-2 BY FISH?

The **HER-2 by FISH (Fluorescence In Situ Hybridization)** test is a specialized diagnostic procedure used to detect **HER2 gene amplification** in cancer tissue, most commonly breast cancer. By analyzing tumor samples, this test determines whether the HER2 gene is overexpressed, which plays a crucial role in guiding targeted therapies such as trastuzumab. Healthcare professionals recommend this test to confirm HER2 status when immunohistochemistry results are equivocal, ensuring accurate diagnosis and personalized treatment planning for patients.

Additional Information

Also known as/ Other names: HER2 FISH Test, HER2 Gene Amplification by FISH, HER2/neu FISH Analysis, Fluorescence In Situ Hybridization for HER2
Parameters: 1
Recommended for: M/F/Others
Sample Type: FFPE Tissue block
Patient Preparation: No prior preparation is needed
Reports: 6 days

FAQs

Why is the HER-2 test important?

It helps determine whether a patient’s tumor overexpresses HER2, which influences treatment options like trastuzumab or pertuzumab.

Who should undergo the HER-2 by FISH test?

Patients diagnosed with breast cancer or gastric cancer are often recommended this test to guide therapy.

What does a positive HER-2 result mean?

It indicates HER2 gene amplification, suggesting the patient may benefit from HER2-targeted therapies.

What does a negative HER-2 result mean?

It means the tumor does not overexpress HER2, so HER2-targeted therapies may not be effective.

Can HER-2 status change over time?

Yes, HER2 expression may change, so repeat testing can be recommended if cancer recurs or progresses.

Is HER-2 by FISH more accurate than IHC?

Certainly, FISH is considered the gold standard when immunohistochemistry (IHC) results are equivocal or borderline.

Can HER-2 by FISH be done on all cancers?

It is mainly used for breast and gastric cancers, not routinely for other cancers.

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