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What is a MPO - ANTI NEUTROPHILIC CYTOPLASMIC ANTIBODY (P-ANCA)?

MPO–ANCA, also called the P-ANCA test, is a blood test that detects autoantibodies targeting myeloperoxidase, a protein found in certain white blood cells. It is needed to support the evaluation of autoimmune diseases affecting small blood vessels, particularly microscopic polyangiitis and eosinophilic granulomatosis with polyangiitis. The test may also help investigate unexplained kidney, lung, skin, or systemic inflammation, but results require clinical correlation.

Additional Information

Also known as/ Other names: MPO Antibody Test, P-ANCA (MPO) Test, Myeloperoxidase Antibody, Anti-MPO Antibody Test
Parameters: 1
Recommended for: M/F/Others
Sample Type: Blood
Patient Preparation: Overnight fasting is preferred.
Reports: Same Day

FAQs

What does MPO stand for?

MPO stands for myeloperoxidase.

What does ANCA stand for?

ANCA stands for antineutrophil cytoplasmic antibody.

What does P-ANCA mean?

P-ANCA refers to a perinuclear staining pattern seen when ANCA antibodies are examined by immunofluorescence. MPO is the most common target associated with this pattern.

Why is the MPO–ANCA test done?

It helps evaluate suspected autoimmune inflammation of small blood vessels, known as ANCA-associated vasculitis.

Which conditions are associated with MPO–ANCA?

It is commonly associated with microscopic polyangiitis and may occur in eosinophilic granulomatosis with polyangiitis and other autoimmune conditions.

What symptoms may lead to this test?

Unexplained kidney inflammation, blood or protein in the urine, lung bleeding, breathing problems, nerve symptoms, skin rashes, or persistent systemic inflammation may prompt testing.

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