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What is a MSI BY FRAGMENT ANALYSIS?

The MSI (Microsatellite Instability) by Fragment Analysis test is a molecular diagnostic test used to detect genetic changes in microsatellite regions of DNA. Microsatellite instability occurs when the DNA mismatch repair system is defective, leading to errors in repetitive DNA sequences. This test is particularly important in colorectal and endometrial cancers, as MSI status helps identify patients with Lynch syndrome, predict prognosis, and guide treatment decisions, including suitability for immunotherapy. It provides valuable insights into personalized cancer management.

Additional Information

Also known as/ Other names: Microsatellite Instability Testing, MSI Fragment Analysis Test, MSI Molecular Analysis, Microsatellite Instability Assay
Parameters: 1
Recommended for: M/F/Others
Sample Type: FFPE Tissue block
Patient Preparation: No prior preparation is needed
Reports: 10 days

FAQs

Can MSI testing confirm Lynch syndrome?

Yes, MSI positivity strongly suggests defective mismatch repair, which is a hallmark of Lynch syndrome, though genetic testing is needed for confirmation.

Is MSI testing useful in colorectal cancer only?

No, it is also valuable in endometrial, gastric, and other cancers where mismatch repair defects may occur.

Can MSI results predict response to immunotherapy?

Yes, MSI-high tumors often respond better to immune checkpoint inhibitors, guiding treatment decisions.

Does MSI testing replace genetic testing?

No, MSI testing detects instability, but genetic testing is required to confirm inherited mutations in mismatch repair genes.

Can MSI testing be combined with IHC?

Yes, combining fragment analysis with immunohistochemistry provides a more complete assessment of mismatch repair status.

Does MSI status affect prognosis?

Yes, MSI-high colorectal cancers often have a better prognosis compared to microsatellite-stable tumors.

Can MSI testing detect all mismatch repair defects?

It detects instability in microsatellite regions, but some defects may require complementary methods like IHC or sequencing.

Is MSI testing recommended for all colorectal cancer patients?

Yes, guidelines recommend MSI testing in all colorectal cancer cases to identify Lynch syndrome and guide therapy.

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