Protein C Functional is a blood test that measures the activity of Protein C, a natural anticoagulant that helps regulate blood clot formation. The test is needed to evaluate suspected Protein C deficiency, which can increase the risk of abnormal blood clots, particularly venous thrombosis. It may be recommended in individuals with unexplained or recurrent blood clots, thrombosis at a young age, or a family history of clotting disorders.
Protein C is a vitamin K-dependent protein produced mainly by the liver. When activated, it helps control clotting by inactivating certain clotting factors.
Low Protein C activity may indicate Protein C deficiency or may occur temporarily with certain illnesses, liver disorders, vitamin K deficiency, or anticoagulant treatment.
Protein C deficiency is a condition in which Protein C levels or activity are lower than expected, potentially increasing the tendency to develop abnormal blood clots.
Yes. Some cases are caused by inherited changes in the PROC gene and may run in families. Other cases are acquired due to medical conditions or medications.
Protein C deficiency is particularly associated with an increased risk of venous thromboembolism, including deep vein thrombosis and pulmonary embolism.