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What is a PROTEIN ELECTROPHORESIS SERUM?

Serum Protein Electrophoresis (SPEP) is a blood test that separates and measures different proteins in the blood based on their electrical properties. It helps evaluate abnormalities in protein levels and patterns, including changes in albumin and immunoglobulins. The test is needed to investigate conditions such as multiple myeloma, monoclonal gammopathies, chronic inflammation, liver disease, kidney disorders, and unexplained abnormalities in total protein levels.

Additional Information

Parameters: 1
Recommended for: M/F/Others
Sample Type: Blood
Patient Preparation: No prior preparation is needed
Reports: Same Day

FAQs

Which proteins are evaluated by SPEP?

SPEP typically separates serum proteins into albumin, alpha-1, alpha-2, beta, and gamma fractions. Changes in these fractions can provide clues about certain diseases.

What is the albumin fraction?

Albumin is the most abundant protein in blood and helps maintain fluid balance and transport various substances. Abnormal albumin levels may occur with liver disease, kidney disease, malnutrition, or other conditions.

What is the gamma region in protein electrophoresis?

The gamma region contains many immunoglobulins, or antibodies. Changes in this region can occur with infections, inflammation, immune disorders, and monoclonal protein production.

What is an M-protein or monoclonal protein?

An M-protein is an abnormal immunoglobulin produced by a single population of plasma cells or B cells. Its presence may require further testing to determine its significance.

Can SPEP detect multiple myeloma?

SPEP can identify protein patterns suggestive of a monoclonal protein associated with multiple myeloma, but it cannot diagnose multiple myeloma by itself. Additional tests are generally required.

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