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What is a SCL-70 SCLERODERMA ANTIBODY?

Scl-70 Scleroderma Antibody is a blood test that detects antibodies against topoisomerase I, also known as Scl-70. These autoantibodies are associated particularly with systemic sclerosis (scleroderma). The test is needed to support the evaluation of individuals with symptoms suggestive of systemic sclerosis, such as skin thickening, Raynaud’s phenomenon, or other organ involvement. Results are interpreted alongside clinical findings and other autoimmune tests.

Additional Information

Also known as/ Other names: Anti-SCL-70 Antibody Test, Anti-Topoisomerase I Antibody, Scleroderma Antibody Test, SCL-70 Autoantibody Assay, Anti-SCL-70 IgG, Topoisomerase I Antibody Test
Parameters: 1
Recommended for: M/F/Others
Sample Type: Blood
Patient Preparation: No prior preparation is needed
Reports: 3 Days

FAQs

What is systemic sclerosis?

Systemic sclerosis is an autoimmune condition that can cause hardening and thickening of the skin and may affect internal organs, including the lungs, kidneys, heart, and digestive system.

What does a positive Scl-70 antibody result mean?

A positive result indicates that Scl-70 antibodies have been detected. In the appropriate clinical setting, this can support a diagnosis of systemic sclerosis.

Does a positive Scl-70 result confirm scleroderma?

No. The result should not be interpreted on its own. Diagnosis is based on clinical features, physical examination, antibody testing, and other investigations.

What does a negative Scl-70 result mean?

A negative result means Scl-70 antibodies were not detected. However, systemic sclerosis cannot be completely ruled out because not all affected individuals have Scl-70 antibodies.

What is Raynaud’s phenomenon?

Raynaud’s phenomenon causes fingers or toes to change colour and become cold or painful in response to cold temperatures or stress. It can occur independently or as part of an autoimmune condition.

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