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What is a SYNOVIAL SARCOMA (SS18/SYT) 18q11.2 GENE REARRANGEMENT BY FISH?

The Synovial Sarcoma (SS18/SYT) 18q11.2 Gene Rearrangement by FISH test is a specialized molecular diagnostic used to confirm synovial sarcoma, a rare soft tissue cancer. This test employs Fluorescence In Situ Hybridization (FISH) to detect characteristic chromosomal translocations involving the SS18 gene at 18q11.2. It is performed on tumor tissue samples to provide definitive diagnosis, especially when histology is inconclusive, ensuring accurate classification and guiding appropriate treatment planning for patients with suspected synovial sarcoma.

Additional Information

Also known as/ Other names: SS18 (SYT) Gene Rearrangement FISH, SYT (18q11.2) Break Apart FISH, Synovial Sarcoma SS18 FISH Assay, SS18 Dual-Color Break Apart FISH
Parameters: 1
Recommended for: M/F/Others
Sample Type: FFPE tissue block (≥10% tumor), ship at room temperature.
Patient Preparation: No prior preparation is needed
Reports: 6 Days

FAQs

Who should undergo this test?

Patients with suspected soft tissue sarcoma, especially when pathology suggests synovial sarcoma, benefit from this test.

Why is this test recommended?

It provides definitive confirmation of synovial sarcoma when histology or immunohistochemistry results are inconclusive.

What condition does the test detect?

It specifically detects synovial sarcoma by identifying the SS18/SYT gene rearrangement.

Can this test confirm a diagnosis?

Yes, it provides definitive evidence of synovial sarcoma when gene rearrangement is detected.

Is genetic counseling necessary after testing?

No, this test is diagnostic for cancer, not hereditary risk, so counseling is not required.

Can the test predict disease severity?

No, it confirms diagnosis but does not predict tumor aggressiveness or prognosis.

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