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What is a TISSUE TRANSGLUTAMINASE IGG (TTG)?

The Tissue Transglutaminase IgG (tTG-IgG) test is a blood test primarily used to help diagnose celiac disease, an autoimmune condition triggered by gluten consumption. It measures IgG antibodies against tissue transglutaminase, an enzyme involved in intestinal tissue repair. This test is especially useful for individuals who cannot produce reliable IgA antibodies or have IgA deficiency. Healthcare professionals recommend it to evaluate gluten sensitivity, confirm suspected celiac disease, and monitor response to a gluten-free diet, ensuring accurate diagnosis and effective management.

Additional Information

Also known as/ Other names: Anti-Tissue Transglutaminase IgG, TTG IgG Test, Celiac Disease Antibody IgG Test
Parameters: 1
Recommended for: M/F/Others
Sample Type: Blood
Patient Preparation: No prior preparation is needed
Reports: Next Day

FAQs

What does a positive tTG-IgG result mean?

It suggests possible celiac disease or gluten sensitivity, requiring further evaluation and confirmatory tests like biopsy.

What does a negative tTG-IgG result mean?

It usually indicates no active autoimmune reaction to gluten, though other tests may be needed for confirmation.

Is the tTG-IgG test useful in IgA deficiency?

Yes, it’s particularly important for patients who cannot produce reliable IgA antibodies.

Is the tTG-IgG test used in children?

Yes, it’s often used in children suspected of having celiac disease, especially with IgA deficiency.

Can gluten-free diet affect test results?

Yes, starting a gluten-free diet before testing may lower antibody levels, leading to false negatives.

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