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What is a TPMT & NUDT15 GENOTYPING by RT-PCR?

The **TPMT & NUDT15 Genotyping by RT-PCR** test is a genetic analysis used to detect variations in the *TPMT* (Thiopurine S-methyltransferase) and *NUDT15* (Nudix Hydrolase 15) genes. These genes influence how the body metabolizes thiopurine drugs, which are commonly prescribed for conditions like leukemia, inflammatory bowel disease, and autoimmune disorders. Doctors order this test to identify patients at risk of severe drug toxicity, allowing them to tailor medication doses safely and prevent harmful side effects during treatment.

Additional Information

Also known as/ Other names: TPMT & NUDT15 DNA Analysis, Thiopurine Sensitivity Genetic Screen, TPMT/NUDT15 Polymorphism Detection (RT‑PCR)
Parameters: 1
Recommended for: M/F/Others
Sample Type: Blood
Patient Preparation: No prior preparation is needed
Reports: 7 Days

FAQs

Can this test predict drug toxicity before treatment?

Yes, it identifies genetic variations that increase risk of severe side effects from thiopurine drugs, allowing safer treatment planning.

Is genetic counseling recommended after this test?

Certainly, counseling helps patients understand results, inheritance patterns, and implications for family members.

Is the test useful for bone marrow suppression risk?

Yes, it predicts susceptibility to severe bone marrow toxicity from thiopurine drugs.

Can results change over time?

No, genetic variations remain constant throughout life, so repeat testing is not needed.

Is the test reliable for prognosis?

Yes, it helps predict risk of adverse drug reactions and guides safe therapy.

Can the test monitor treatment progress?

No, it predicts risk before therapy but does not monitor ongoing treatment.

Is the test used for leukemia patients?

Yes, it helps optimize thiopurine therapy in leukemia treatment.

Can medications affect test results?

No, this is a genetic test, so medications do not alter results.

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