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What is a VITAMIN D, 1, 25-DIHYDROXY?

Vitamin D, 1,25-Dihydroxy is a blood test that measures the active form of vitamin D, also known as calcitriol. This hormone plays an important role in regulating calcium and phosphorus levels and maintaining healthy bones. The test is needed to evaluate certain disorders of calcium metabolism, kidney function, and abnormal vitamin D regulation, particularly when routine 25-hydroxy vitamin D testing does not provide sufficient information.

Additional Information

Also known as/ Other names: Calcitriol Test, 1,25(OH)₂D Test, Serum Calcitriol Test, Active Vitamin D Test, 1,25-Dihydroxycholecalciferol Test
Parameters: 1
Recommended for: M/F/Others
Sample Type: Blood
Patient Preparation: No prior preparation is needed
Reports: Next Day

FAQs

What is calcitriol?

Calcitriol is the active form of vitamin D. It helps regulate calcium and phosphorus absorption and plays an important role in maintaining bone and mineral health.

Why is 1,25-dihydroxy vitamin D called the active form?

Vitamin D undergoes several steps of activation in the body. The kidneys convert 25-hydroxyvitamin D into 1,25-dihydroxyvitamin D, which carries out many of vitamin D's biological effects.

When is 1,25-dihydroxy vitamin D testing preferred?

It may be considered when there are unexplained abnormalities in calcium or phosphorus, certain kidney disorders, abnormal parathyroid function, or suspected disorders of vitamin D metabolism.

Can this test diagnose Vitamin D deficiency?

It is generally not the preferred test for routine vitamin D deficiency. The 25-hydroxyvitamin D test is typically used to assess vitamin D stores and nutritional status.

What can cause a high 1,25-dihydroxy vitamin D level?

Elevated levels can occur in certain disorders involving increased vitamin D activation, including some granulomatous diseases and lymphomas, as well as certain calcium-regulating disorders.

What can cause a low 1,25-dihydroxy vitamin D level?

Low levels may occur with advanced kidney disease, certain disorders affecting vitamin D metabolism, or reduced availability of the precursor needed for activation.

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